Biophysical and Structural Aspects of BioenergeticsMårten Wikström Bioenergetics is a term used to describe the events of primary energy transduction in biology. The field has seen tremendous advances in recent years thanks to developments in the biophysical and computational techniques used to solve the three-dimensional structures of the membrane-bound proteins, which often act as catalysts in these reactions. This has enabled researchers to bring, otherwise static, structures to life and decipher the dynamic function of these intriguing systems. Biophysical and Structural Aspects of Bioenergetics brings together contributions from internationally respected experts, all of whom helped shape and develop the field of bioenergetics. It provides a representative snapshot of the very latest key developments in this multidisciplinary subject, with an emphasis on molecular structure, and how this changes during the bioenergetic function. Offering a comprehensive overview of the current state of the art, and complete with extensive citations in each chapter, this book is the ideal reference for both biochemists and biophysicists studying this fascinating topic. |
Contents
Chapter | 1 |
Hysteretic Properties of Cytochrome Oxidase | 13 |
Proton Entry Exit and Pathways | 26 |
5 | 34 |
Gating of the Pump | 49 |
1 | 55 |
Acknowledgements | 69 |
Reduced CcO with | 82 |
Structure of Photosystem II from | 201 |
Chapter 6 | 212 |
Acknowledgements | 222 |
A Structural View of Proton Transport | 227 |
The Dynamics of Proton Transfer Across | 249 |
Group | 267 |
Intraprotein Proton TransferConcepts | 273 |
Infrared Protein Spectroscopy as a Tool | 314 |
Molecular Mechanisms for Proton Pumping | 88 |
Quantum and Proton Chemical Pumping Models in Cytochrome of O2 Bond Oxidase | 99 |
Mechanism for Proton | 110 |
Proton Gating or Guiding | 117 |
Chapter 7 | 156 |
References | 180 |
Current Knowledge About the Mechanism | 185 |
Outlook | 331 |
Concluding Remarks | 353 |
1 | 359 |
Hydride Transfer and Proton Translocation | 376 |
Considerations Relevant to the Mechanism | 383 |
Future Directions | 390 |
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Common terms and phrases
Acad acceptor Acta active amino acids atom ATP synthase ATPase aurovertin bacteriorhodopsin bands binding binuclear center Biochemistry Biochim Biol Biophys bovine carboxylic catalytic Chem cluster N2 cmJ1 cofactors complex conserved coupled cytochrome oxidase cytoplasmic D-channel deprotonation difference spectra domain donor electron transfer enzyme FEBS Lett Figure free energy functional helices helix heme histidine hydrogen bond hydrogenases hydrophobic imidazole inhibited inhibitors interaction intermediate J.E. Walker J.K. Lanyi kinetic ligand ligated Mäntele mechanism membrane mitochondrial molecular mutant NADH Natl NiFe Oesterhelt oxidation oxygen pathway photocycle potential Proc propionate protein proton pumping proton transfer proton translocation proton uptake PSII PSST quinone R.B. Gennis reaction centers redox reduction region residues retinal Rhodobacter Rhodobacter sphaeroides Schiff base semiquinone sequence shown spectroscopy spectrum sphaeroides substrate surface tion transition transmembrane tyrosine ubiquinone vibrational water molecules Wikström