Cholinergic Mechanisms

Front Cover
Israel Silman, Hermona Soreq, Lili Anglister, Daniel M. Michaelson, Abraham Fisher
CRC Press, Sep 20, 2004 - Science - 774 pages
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Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.
 

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Contents

Platform presentations
xix
Edith Heilbronn Lecture
1
structure
12
Pharmacological and structural characterization of the interaction of snake toxins
27
The mechanism for acetylcholine receptor inhibition by aneurotoxins and speciesspecific
45
structure
55
Generation and analysis of muscarinic acetylcholine receptor knockout mice
63
Roles of external loops of muscarinic receptors in interactions between
71
Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional
419
The cholinergic system and cognitive and noncognitive behavioral dysfunction
431
Poster presentations
453
The effect of diet restriction separation stress activity wheel and tyrosine administration
455
further considerations on a
463
The agonist biphasic doseresponse curve of human a432 nicotinic acetylcholine receptors
471
Dramatic depletion of cell surface muscarinic receptor due to limited delivery from
477
Quanta acetylcholine release through mediatophore proteolipid
485

Couteaux lecture
77
Presynaptic mechanisms
87
The Cavoltage hypothesis for neurotransmitter release current status
99
Structural and regulatory aspects of the cholinergic synapse
105
Control of expression of nicotinic receptor and acetylcholinesterase in the developing
113
from stressful
119
a mosaic model for regulation
125
Regulation of cholinergic gene expression by NRSFREST
133
Miriam Salpeter Lecture
145
Structural and functional studies on cholinesterases
155
direct nonperturbing monitoring of
171
Surprising findings from the functional analysis of human acetylcholinesterase
177
Crystal structure of the tetramerization domain of acetylcholinesterase at 2 3 A resolution
183
Regulation of cholinergic neurotransmitter phenotypes
193
Molecular and functional diversity in the nicotinic acetylcholine receptor gene families of
199
Genetic dissection of an acetylcholine receptor involved in neuronal degeneration
207
Autoimmune diseases related to the cholinergic synapse
213
Antibodies to acetylcholine receptors and MuSK in myasthenia gravis and related disorders
227
Muscarinic receptor autoantibodies in Sjogrens syndrome
233
antigenspecific mucosal tolerance and
241
Toxicology and pharmacology of cholinesterase inhibitors
245
Therapeutic efficacy in organophosphate poisoning by inhibiting central release of acetylcholine
255
organophosphatesensing matrixes
265
Sex differences in the actions of cholinesterase inhibitors
271
Bifunctional compounds eliciting both antiinflammatory and cholinergic activity as
277
Brzin Lecture
289
Pharmacology of nicotinic and muscarinic receptors in the
297
Common structural and pharmacological properties of serotonin 5HT3 receptors and
309
Preclinical studies of galantamine using a form of associative learning severely impaired in
323
New evidence for the involvement of muscarinic cholinergic receptors in psychoses
331
Cholinergicamyloid crosstalk
345
PKC and MAP kinasedependent processing of amyloid precursor protein APP by
353
role of A3AChE complexes
363
The effects of apoE3 and apoE4 on lipid synthesis and uptake
369
Cholinergic pathways and regulation in the
375
possible role of neurotrophins in target selection
381
Activation of the cholinergic system during cognitive processes
387
How is the brain protected against excess choline concentrations?
395
regulation of structure and functions
405
Clinical studies on Alzheimer patients
411
Cholinergic modulation of chemotaxis in human melanoma cells
493
Muscarinic neuromodulation in the hippocampus and parahippocampal region
499
In vivo cholinergic effects in the rat of headtotail 3alkylpiridinium polymers
507
NFKB regulates the promoter activity of human acetylcholinesterase in muscle
515
Interaction of recombinant soluble neuroligin1 with neurexinl3
523
Buprofezin and novaluron inhibit acetylcholinesterase activity in Bbiotype Bemisia tabaci
531
Identification of species differences in the pharmacology of the cx7 nicotinic
539
Calcium mobilization and cellular contraction of embryonic lens vesicle and
555
a tool for
563
332 subunits
571
a specific inhibitor of insecticideresistant acetylcholinesterase
581
Influence of water on the function of acetylcholinesterase
589
Investigating the diversity of acetylcholinesterase in insect species
595
Attempts to engineer an enzyme mimic of butyrylcholinesterase by substitution of
601
Mapping the acetylcholinebinding sites of Torpedo nicotinic receptor using
607
Some basic rules governing oligosaccharidedependent circulatory residence of
613
Muscarinic acetylcholine receptors are downregulated in acetylcholinesterase knockout mice
619
Two possible orientations of the HI6 molecule in the reactivation of
627
Formation of neuromuscular junctions in cocultures of human muscle and
635
mRNAs encoding acetylcholinesterase butyrylcholinesterase and agrin 19 share the
641
Brain penetration and behavioral properties of a potent a 7 nicotinic acetylcholine receptor
649
Hydrocortisone affects the densities of cardiac muscarinic and adrenergic receptors
653
a possible peripheral marker
659
Segregation of phosphatidic acidrich domains in reconstituted acetylcholine
665
Peripheral binding of ethopropazine to horse serum butyrylcholinesterase
673
cellular models
679
Variability of substrate specificity in cholinesterases of vertebrates and invertebrates
685
Overexpression of the extracellular and cytoplasmic domains of the Drosophila
687
Ligandinduced conformational changes in the omega loop of acetylcholinesterase
695
Comparison of two reaction schemes for the hydrolysis of acetylthiocholine
701
Twohybrid approach to the intracellular functions of readthrough acetylcholinesterase
707
Effects of carbamate insecticides on rat neuronal a434 nicotinic receptors and
715
Significance of parameters in various kinetic schemes for cholinesterases
721
a 5ns molecular dynamics simulation
727
Huperzine A a promising antiAlzheimers agent reduces staurosporineinduced apoptosis
733
Effects of lithium chloride on memory performances of mice in an elevated plusmaze test
739
Nicotinic cholinergic activation of magnocellular endocrine neurons of the hypothalamus
745
Neuroprotective effects of huperzine A and donepezil on staurosporineinduced injury in
751
Cloning and characterization of the acetylcholinesterase gene in the chicken
757
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