Physical Biology: From Atoms to Medicine

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Imperial College Press, 2008 - Science - 567 pages
This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology.This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function.The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine.

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User Review  - cepheid36552 - LibraryThing

Although this is definitely designed for people currently in the field, there are a lot of interesting ideas in here. For example, one can get a sense of the directions in which the field is tending ... Read full review


Chapter 2 The World as Physics Mathematics and Nothing Else Alexander Varshavsky
4D Visualization of Complexity Ahmed H Zewail
Chapter 4 Revolutionary Developments from Atomic to Extended Structural Imaging John Meurig Thomas
Chapter 5 Physical Biology at the Crossroads Carlos J Bustamante
Chapter 6 The Challenge of QuasiRegular Structures in Biology Roger D Kornberg
Chapter 7 The Future of Biological XRay Analysis Douglas C Rees
Implications for Macromolecular Design Evolution and Analysis David A Tirrell
Chapter 9 Designing Ligands to Bind Tightly to Proteins George M Whitesides Phillip W Snyder Demetri T Moustakas and Katherine A Mirica
Energy Landscapes and the Organization of Living Matter in Time and Space Peter G Wolynes
From Atoms to Organisms Christopher M Dobson
Chapter 14 A Systems Approach to Medicine Will Transform Healthcare Leroy Hood
Chapter 15 The Neurobiology of Consciousness Christof Koch and Florian Mormann
Physicsbased Simulations from the Molecular to the Cellular Level J Andrew McCammon
Chapter 17 Precision Measurements in Biology Stephen R Quake
Chapter 18 Potassium Channels and the Atomic Basis of Selective Ion Conduction Roderick MacKinnon
The 2007 Welch Award Papers

Chapter 10 Biology by the Numbers Rob Phillips
Chapter 11 Eppur si muove Michele Parrinello

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