I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelino pathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the literature up to summer 1988. All refer ences were double checked for errors. My gratitude goes to Mrs. Gisela Ropte and Mrs. Cynthia Bunker for their untiring, diligent help. As a result, this second edition is an essentially rewritten text. Advance in the prevention of human suffering is based on a thorough understand ing of the nature of disease. I hope that this text will continue to be of service in this behalf. Perhaps it may also reflect and foster the intellectual curiosity which makes the "reading of brains" so interesting an occupation. Gottingen, 1989 Reinhard L.
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Gross and Microscopic Development of the Central Nervous System
Some Features of Basic Reactions Characteristic for Immature
Porencephaly Hydranencephaly Multicystic Encephalopathy
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abnormal acid Acta Neuropathol Berl adrenoleukodystrophy adult agenesis anencephaly aneurysm anomalies aplasia aqueduct arachnoid cysts Arch Dis Child Arch Neurol Arch Pathol Arnold-Chiari Arnold-Chiari malformation arteries associated astrocytes atrophy axon basal ganglia birth brain stem central nervous system cerebellar cerebellum cerebral cortex changes Chap choroid plexus chronic clinical congenital corpus callosum cortical cranial cytoplasm defects deficiency degeneration described disease dorsal dysplasia Electron microscopic encephalocele encephalopathy enzyme fetal fibers fluid Friede glial gliosis granular layer granules gyri hemispheres hemorrhage herniation heterotopias hydranencephaly hydrocephalus hypoplasia infantile infants infection intracranial kernicterus leptomeninges lesions leukodystrophy lipid malformation membrane meningitis metabolic microcephaly mitochondrial myelin necrosis neonatal nerve Neurol Neurosurg Psychiatry Neurology Neuropathol Exp Neurol newborn normal nuclei occipital pathology patients Pediatr perinatal polymicrogyria porencephaly postnatal reported sinus spina bifida spinal cord spongy subarachnoid subdural hematomas syndrome tion tissue tracts vascular ventricles ventricular vermis white matter