Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies

Front Cover
John Wiley & Sons, Sep 29, 2014 - Medical - 368 pages


With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addiction and covers specific drugs of abuse including narcotics, stimulants, depressants, nicotine, and marijuana.

• Interprets complex neuro- biological and pharmacological information, like the drug-reward system, for medicinal chemists
• Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs
• Pulls together information on the many potential drug targets for treating addiction
• Stresses unique medicinal chemistry problems when describing pharmacology testing methods and drug development

 

Selected pages

Contents

Physiological Basis of AddictionA Chemists Interpretation
18
Behavioral Pharmacology and Addiction
76
Medication Development for Stimulant Addiction
160
Medication Development for Depressant Addiction
213
Medication Development for Nicotine Addiction
230
Medication Development for Marijuana Addiction
240
Designer Drugs
252
Conclusion
259
CONTENTS
262
Glossary of Terms Used in Medicinal Chemistry
271
References
290
Index
335
Copyright

Other editions - View all

Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies
Brian S. Fulton
Limited preview - 2014

Common terms and phrases

abuse accumbens acid acting action activity affinity agonist alcohol allosteric animal antagonist appears assay associated attenuate behavior binding brain causes cell changes chemical chemistry clinical trials cocaine complex compound concentration conditioned containing cortex decrease dependence determined discovery discussed disorders dopamine dose drug addiction effects example Figure functional GABA glutamate human important increase inhibition inhibitor interaction interest involved ion channels lead levels ligand located measured mechanism MEDICATION DEVELOPMENT medicinal medicinal chemistry methamphetamine mGlu mice models modulators molecular morphine neurons neurotransmitter nicotine Note nucleus occurs opioid partial patients Pharmacol pharmacological positive potential present produce properties protein rats receptor reduced REFERENCES reinforcing reinstatement relapse release reported response reward role selective self-administration showed similar specific STIMULANT structure subjects substance suggests synapse synthesis term transporters treat treatment United withdrawal

About the author (2014)

Brian S. Fulton is a Visiting Lecturer in the Department of Chemistry and Chemical Biology at Northeastern University and has taught courses in organic chemistry, spectroscopy, and pharmaceutical sciences and has taught a one-semester course, Medicinal Chemistry of Psychiatric Drugs, at Harvard University Extension School. From 1987 – 2005, Dr. Fulton worked as an industrial organic chemist in the US and Europe. He obtained his B.S. in Chemistry at Missouri State University and his Ph.D. in Organic Chemistry at Iowa State University. He has written 17 peer-reviewed publications and given 8 presentations at scientific meetings.

Bibliographic information

TitleDrug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies
AuthorBrian S. Fulton
Editionillustrated, reprint
PublisherJohn Wiley & Sons, 2014
ISBN0470614161, 9780470614167
Length368 pages
Subjects ›  › 

Medical / Neuroscience
Medical / Pharmacology
Science / Chemistry / General
Science / Chemistry / Organic
  
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