Clinical Trials: A Practical ApproachThis comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience. |
Contents
3 | 60 |
Methods of Randomization | 66 |
Blinding and Placebos 90 2005 | 90 |
Copyright | |
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accrual achieved anturan approach aspects assessment bias blood pressure breast cancer cancer trial centre chapter chemotherapy clinical research clinical trials clinician clofibrate compared confidence limits consider control group crossover trials death described discussed disease dose double-blind effect eligible ensure ethical evidence example follow-up Hence historical controls hypertension ineligible patients instance interim analyses interpretation investigators issue L-Pam large number logrank test mastectomy mean measure metoprolol mortality multi-centre trial myocardial infarction needs null hypothesis number of patients observed overall oxprenolol P-value p₁ patient enters patient evaluation patient factors percentage phase pirbuterol placebo practice problem prognostic factors Propranolol randomization list randomized controlled trials randomized trial relevant salbutamol scientific side-effects significance tests standard deviation standard error statistical analysis statistical methods stopping rule study protocol therapeutic toxicity treatment assignment treatment comparison treatment difference treatment groups trial organizers type I error vitamin vitamin D