Fundamentals of Analytical Toxicology: Clinical and Forensic

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John Wiley & Sons, Aug 3, 2020 - Science - 648 pages

Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques.

This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results.

Written by a prominent team of experienced practitioners, this volume:
  • Focuses on analytical, statistical, and pharmacokinetic principles
  • Describes basic methodology, including colour tests and immunoassay and enzyme-based assays
  • Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation
  • Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides
  • Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)

Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.

 

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Contents

Use of internal standards
3
2
7
2 2 Systematic toxicological analysis 6
8
Quantitative mass spectrometry
13
References
21
Sample Collection Transport and Storage
23
Guidelines for sample collection for analytical toxicology
33
Sample transport storage and disposal
45
References
402
56
403
ANALYTICAL TOXICOLOGY
405
60
417
Laboratory Testing for Substance Misuse
422
8
446
References
447
61
448

Basic Laboratory Operations
52
Aspects of Sample Preparation
94
Colour Tests and Spectrophotometric and Luminescence Techniques
120
Immunoassays and Related Assays
145
5 Microparticulate and turbidimetric immunoassays 6 5 1 Microparticle enzyme immunoassay MEIA
159
SECTION B SEPARATION SCIENCE
167
References
181
References
192
Headspace and purge and trap analysis
210
Chiral separations
217
Liquid Chromatography
223
9
237
206
262
Supercritical Fluid Chromatography
264
210
272
References
273
4
278
References
287
213
288
280
318
217
319
Mass spectrometry imaging
324
2
331
ESSENTIAL PHARMACOKINETICS
345
52
377
220
451
356
461
224
470
6 1 Qualitative analysis 19 6 1 1 Targeted analysis
471
282
472
Therapeutic Drug Monitoring
479
Antiinfectives
488
Cardioactive drugs
495
Trace Elements and Toxic Metals
505
Colorimetry and fluorimetry
520
Index
556
Organophosphorus compounds
568
Sources of further information
574
283
580
556
581
358
587
231
588
287
589
270
592
505
593
379
594
313
595
237
597
Copyright

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About the author (2020)

Robert J Flanagan, Precision Medicine, King's College Hospital NHS Foundation Trust, UK, and Specialised Clinical Chemistry, Sheffield Teaching Hospitals NHS Foundation Trust, UK.

EVA CUYPERS, Maastricht Multimodal Molecular Imaging Institute, University of Maastricht, The Netherlands, and KU Leuven Toxicology and Pharmacology, Belgium.

HANS H. MAURER, Department of Experimental and Clinical Toxicology, Saarland University, Germany.

ROBIN WHELPTON, Formerly School of Biological and Chemical Sciences, Queen Mary University of London, UK.

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