Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond
Joseph D. Puglisi
Springer Science & Business Media, Mar 21, 2007 - Science - 155 pages
This volume is a collection of articles from the Proceedings of the International School of Structural Biology and Magnetic Resonance 7th Course: Structure, Structure and Biophysics – New Technologies for Current Challenges in Biology and Beyond. This NATO Advance Study Institute (ASI) was held in Erice (Italy) at the Ettore Majorana Foundation and Centre for Scientific Culture on 22 June through 3 July 2005. The ASI brought together a diverse group of experts in the fields of structural biology, biophysics, and physics. Prominent lecturers, from seven different countries, and students from around the world participated in the NATO ASI organized by Professors Joseph Puglisi (Stanford University, California, USA) and Alexander Arseniev (Moscow, RU). Advances in nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography have allowed the thr- dimensional structures of many biological macromolecules and their complexes, including the ribosome and RNA polymerase to be solved. Fundamental principles of NMR spectroscopy and dynamics, X-ray crystallography, computation, and experimental dynamics were taught in the context of important biological applications. The ASI addressed the treatment and detection of bioterrorism agents, and focused on critical partner country priorities in biotechnology, materials, and drug discovery. The range of topics here represents the diversity of critical problems between structural biology, biochemistry, and biophysics, in which lies the fertile ground of drug development, biotechnology, and new materials. The individual articles represent the state of the art in each area and provide a guide to the original literature in this rapidly developing field.
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Structure and Biophysics - New Technologies for Current Challenges in ...
Joseph D. Puglisi
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A-site tRNA adenine Agmon amino acid antibiotics atoms backbone Baram Bashan binding modes Biol Biomol catalytic cell Chem chemical shift coli conformation correlation couplings crystal crystallographic dimer dissociation distribution DMPC domain-swapped dimer DPPC drug dsRNA dynamics energy ensemble environment enzyme eubacteria eukaryotic experimental Figure folding genomes helix HSQC hydrophobic indicated inhibitors interactions interface kinase domain kinetic large RNA ligand lipid bilayers loop Lukavsky macrolide Max Perutz MD simulations membrane micelles molecular molecules monomer mutant N-terminal nascent chain NMR experiments NMR spectroscopy NMR structure nucleotides observed P-site parameters peak peptide bond peptide bond formation phosphorylation PKRP posterior proteomics protons Puglisi RDCs reaction region repressor residues ribose sample Schluenzen sequence side-by-side dimer spectra stability structural proteomics structure determination substrate surface TACE tandem complex targets techniques torsion angle tRNA TROSY trp repressor tryptophan tunnel wild-type X-ray X-ray crystallography Yonath