Environmental Radiation Effects on Mammals: A Dynamical Modeling Approach
Themonographisdevotedtothetheoreticalstudiesofradiationeffectsonmammals. It summarizes the results obtained by the author over the past 30 years, most of them being of high priority. In the course of these studies, a single approach to the modeling of radiation effects on mammals has been elaborated. Speci?cally, in the framework of the developed deterministic mathematical models, the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems (hematopoiesis, small intestine, and humoral immunity), as well as on the development of autoimmune diseases, are investigated. The radiation effects on the mortality dynamics in homogeneous and nonhomogeneous(in radiosensitivity) mammalian populations are also studied by making use of the developed stochastic models. The most appealing feature of these mortality models consists of the fact that they account for the intrinsic properties of the exposed organism. Namely, within these models the stochastic biometrical functions are calculated proceeding from statistical characteristics and dynamics of the respective critical body system (hematopoiesis or small intestine). The performed theoretical investigations contribute to the development of the system and quantitative approaches in radiation biology and ecology. These studies elucidate the major regulatory mechanisms of the damage and recovery processes running in the vital body systems of exposed mammals and reveal the key par- eters characterizing the processes.
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Chapter 3 The Small Intestine as a Target for Radiation
Chapter 4 Radiation and Humoral Immunity
Chapter 5 Modeling of Autoimmune Processes
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acute irradiation acute radiation syndrome antibodies antigen biometric functions bone marrow chronic irradiation concentrations of X1 critical system cyclic cytotoxic T-lymphocytes damaged decrease dimensionless dose rate equivalent erythropoiesis experimental data exposed to acute exposed to chronic exposure functional cells granulocyte granulocyte concentration granulocytopoiesis system Gy/day curve homogeneous population humoral immune immune response integral curves intestinal epithelium system ionizing radiation irradiated mammals irradiation at dose irradiation days Journal of Theoretical kinetics log-normal distribution lymphocytes lymphopoiesis mammalian mammals Mathematical model mitotic modeling results mortality dynamics Moscow nonhomogeneous population nonirradiated numbers of ABs O.A. Mathematical modeling onset of irradiation parameters population of mice postirradiation precursor cells preirradiation Radiobiologiya radioresistance radiosensitivity random variable respectively Russian second singular point simulate small intestinal epithelium Smirnova O.A. Mathematical specific rate specimens stationary concentrations stem cells subpopulations T-lymphocytes Theoretical Biology thrombocyte concentration tissue unexposed X1 and X2 X3 cells