Individual Susceptibility to Genotoxic Agents in the Human Population

Front Cover
Springer Science & Business Media, Dec 6, 2012 - Science - 518 pages
As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B.
 

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Contents

Guidance
1
Epidemiology and Population Monitoring in Genetic
21
An Overview of Approaches for Genetic Monitoring
29
Evaluation of Genotoxic Effects in Human
53
METABOLISM OF GENOTOXIC AGENTS
80
On the Possible Significance of TCDD Receptor
89
Interindividual Differences in Monooxygenase
109
Involvement of Prostaglandin Synthetase
155
Discrimination between Spontaneous and Induced
281
Short Term Tests on Body Fluids
293
Hemoglobin as a Dose Monitor of Alkylating
315
Variations in Sensitivity and DNA Repair
321
Unscheduled DNA Synthesis Induced
333
Individual Variation in DNA Repair in Human Peripheral
349
Influence of Demographic Factors on Unscheduled
359
Individual Variation in Benzoapyrene Metabolism
373

The Use of Immunological and Molecular Biological
163
Interindividual Variation in the DNA Binding
177
Intrinsic Factors that Can Affect Sensitivity
201
Individual Wariability in the Frequency
211
Variations in Mitotic Index and Chromosomal
235
Micronuclei in Cultured Lymphocytes
243
Detection of Mutated Erythrocytes in Man
249
Peripheral Blood Lymphocytes as Indicator
267
CBand Variation in Hypertensive Men 4 17
417
Methods for Evaluating the Effects
427
New Techniques for Detecting Chromosome
441
Epidemiologic Considerations in Assessing
459
For the Evaluation
481
Index
509
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