Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

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Springer Science & Business Media, Sep 25, 2012 - Science - 1064 pages

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

 

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Contents

Chapter 1 Introduction
1
Chapter 2 Signaling Lipids
7
Chapter 3 Preamble to Cytoplasmic Protein Kinases
109
Chapter 4 Cytoplasmic Protein Tyrosine Kinases
136
Chapter 5 Cytoplasmic Protein SerineThreonine Kinases
175
Chapter 6 MitogenActivated Protein Kinase Module
311
Chapter 7 DualSpecificity Protein Kinases
379
Chapter 8 Cytosolic Protein Phosphatases
387
Chapter 11 Signaling Pathways
821
Chapter 12 Conclusion
910
References
919
Notation Rules Aliases and Symbols
1005
List of Currently Used Prefixes and Suffixes
1011
List of Aliases
1015
Complementary Lists of Notations
1044
Index
1051

Chapter 9 Guanosine Triphosphatases and Their Regulators
464
Chapter 10 Other Major Types of Signaling Mediators
647

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