Computational Methods for Three-Dimensional Microscopy Reconstruction

Front Cover
Gabor T. Herman, Joachim Frank
Springer Science & Business Media, Jan 29, 2014 - Mathematics - 260 pages

Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physical models of the object and the image-formation process. Both three-dimensional electron microscopy and X-ray tomography can be captured in the same mathematical framework, leading to closely-related computational approaches, but the methodologies differ in detail and hence pose different challenges. The editors of this volume, Gabor T. Herman and Joachim Frank, are experts in the respective methodologies and present research at the forefront of biological imaging and structural biology.

Computational Methods for Three-Dimensional Microscopy Reconstruction will serve as a useful resource for scholars interested in the development of computational methods for structural biology and cell biology, particularly in the area of 3D imaging and modeling.

 

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Contents

1 Introduction
1
Mathematical Context for the Development of Standards
6
3 Fully Automated Particle Selection and Verificationin SingleParticle CryoEM
43
4 Quantitative Analysis in Iterative Classification Schemes for CryoEM Application
67
A Case Study
97
6 Computational Methods for Electron Tomographyof Influenza Virus
133
7 Reconstruction from Microscopic Projectionswith DefocusGradient and Attenuation Effects
157
8 Soft XRay Tomography Imaging for Biological Samples
187
9 Using Component Trees to Explore Biological Structures
221
Index
256
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