Behavioral Toxicology

Front Cover
Bernard Weiss
Springer Science & Business Media, Mar 9, 2013 - Science - 469 pages
Behavioral toxicology is a young discipline in the United States; so young, in fact, that this is one of its first books. Behavioral questions are bound to play a major role in future scientific work and governmental decisions involving the health effects of environmental contaminants and other chemicals. This role springs from two key problems that face scientists and public agencies required to set acceptable exposure standards or to determine criteria for the toxicity of therapeutic chemicals: How do you evaluate effects that may show up only as subtle functional disturbances? And how do you de tect toxic effects early enough so that they may still be reversible, before they produce major damage? The contributions in this book come from a collection of scientists whose interests span a wide variety of problem areas. The focus is largely on me thodological issues because they represent the most immediate concern of the discipline. We expect that this collection of papers will represent a useful source book for behavioral toxicology for some time. For the past few years, the University of Rochester's Department of Radiation Biology and Biophysics has sponsored a series of international conferences on chemical toxicity, partly as a response to concern over the con sequences to health of the rich chemical soup in which we live. This book is based upon presentations made to the fifth of the series. Held in June, 1972, it was the first formal meeting devoted to behavioral toxicology in this country.
 

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Contents

CHAPTER
1
CHAPTER
8
Discussion
21
General Discussion
27
Results
36
Summary
53
CHAPTER 3
61
Discussion
68
Pertinent Literature
243
Fixed Interval Operant Conditioning
249
Behavioral Research Interface
258
CHAPTER 10
265
The Complementarity of Behavioral and Pathological Methodology
273
Conclusions
283
CHAPTER 11
293
Effects on Avoidance Behavior Under Extinction Procedure
301

CHAPTER 4
77
The Rate Threshold of Blocking
89
Effects of Carbon Monoxide on Eye Movements
96
Effects of Carbon Monoxide on SelfPaced
98
CHAPTER 5
105
Carbon Monoxide
115
References
125
Time Discrimination Thresholds
138
Summary
149
Materials and Methods
158
Subacute and Chronic Anticholinesterase Effects
171
Possible Central Actions of Enzyme Reactivations
187
Human Anticholinesterase Intoxication
196
General Discussion
210
Behavioral Toxicologic Studies of Dieldrin DDT and Ruelene
217
Discussion
235
Summary
306
Subtle and LongTerm Consequences of Prenatal Exposure
320
Summary
342
CHAPTER 13
351
Changes in Blood Pressure and Heart Rate Under FixedRatio
359
Acknowledgment
369
CHAPTER 14
375
Acute Effects of Methamphetamine on Food and WaterReinforced
381
Biochemical and Morphological Effects of Chronic Methamphetamine
392
CHAPTER 15
401
Results
408
Summary
422
CHAPTER 16
429
Author Index
447
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