Genetics of the Immune Response

Front Cover
Erna Moller
Springer Science & Business Media, Mar 8, 2013 - Medical - 316 pages
The 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The topic was selected for several reasons, such as the rapid progress in the genetic analysis of immunoglobulin and MHC genes and the elucidation of the mechanism of switch to different immunoglobulin classes and subclasses. The genetic advances formed a basis for discussions of problems relating to regulation of T cell subsets, mechanisms of activation and regulation of B cell differentiation and an analysis of the network hypothesis. The format of the symposium was arranged so as to include two sessions in the morning and two in the afternoon. Each session was introduced by one speaker, followed by free discussion. The intro ductory lectures are included in the proceedings. The participants summarized their contributions to the discussion in written form. In addi tion to the closed sessions, there was one open session at the Karolinska Institute with lectures by Drs. L. Hood, C. Milstein, D. Baltimore, J. Klein and B. Benacerraf, which are not included in these procee din gs. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation. The Swedish Medical Research Council, the Swedish Cancer Society and the Swedish Ministry of Education and Cultural Affairs also made contri butions.
 

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Contents

The Formation of Antibody Variable Region Genes
5
Organization and Reorganization of Constant Region Genes
23
Discussion
54
Molecular Analysis of MHC Antigens 60
65
Discussion
79
T Cell Repertoire and
91
Discussion
108
Induction and Effector Function of T Cells 119
121
Discussion
215
The Degree of Clonal Elimination in Immunological
233
Discussion
242
Factors Determining Virgin and Postantigenic Repertoires
255
Discussion
265
Is the Network Theory Tautologic?
273
Discussion
285
List of Participants
297

Discussion
127
TCell Growth Factor A Lymphocytotropic Hormone 150
153
Stimulation of a B Cell Subset by AntiImmunoglobulin
205

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