Precision Molecular Pathology of Breast Cancer

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Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil
Springer, Aug 12, 2015 - Medical - 338 pages
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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.

Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

 

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Contents

1 Molecular Basis of Breast Cancer Imaging
1
2 Familial Breast Cancer and Genetic Predisposition in Breast Cancer
15
3 Modelling the Molecular Pathology of Breast Cancer Initiation
39
4 Molecular Pathology of Precancerous Lesions of the Breast
51
Role in Tumor Initiation Progression and Targeted Therapy
63
6 Molecular Pathology of PreInvasive Ductal Carcinoma
78
7 Molecular Pathology of Lobular Carcinoma
95
Hormone Receptor Evaluation and Therapeutic Implications
106
12 MolecularBased Diagnostic Prognostic and Predictive Tests in Breast Cancer
176
13 Role of MicroRNAs in Breast Cancer
197
14 Molecular Pathology of Fibroepithelial Neoplasms of the Breast
219
15 Molecular Features of Mesenchymal Tumors of the Breast
236
16 Molecular Pathology of Breast Cancer Metastasis
271
17 The Molecular Pathology of Chemoresistance During the Therapeutic Response in Breast Cancer
290
18 The Molecular Pathology of Male Breast Cancer
309
19 Specimens for Molecular Testing in Breast Cancer
316

HER2 Evaluation and Role in Targeted Therapy
119
10 Molecular Classification of Breast Cancer
137
Subtypes with Clinical Implications
157

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About the author (2015)

Ashraf Khan, MD, FRCPath
University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Ian O. Ellis, MD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Andrew M. Hanby, BM, FRCPath
St. James University Hospital/University of Leeds, Leeds Institute of Cancer and Pathology, Leeds, West Yorkshire, UK

Ediz F. Cosar, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Emad Rakha, MD, PhD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Dina Kandil, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

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