Hayes' Principles and Methods of ToxicologyA. Wallace Hayes, Claire L. Kruger Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap |
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Hayes' Principles and Methods of Toxicology, Sixth Edition A. Wallace Hayes,Claire L. Kruger Limited preview - 2014 |
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absorption acetaminophen acid activity agents analysis animals ANOVA approach bioassay bioavailability biological biomarkers blood body weight calculated cancer carcinogens cell chemical chronic clearance clinical compartment compound concentration conjugation contaminated cytochrome P450 dioxin distribution dose dose–response Drug Metab effects Environmental enzyme equation estimate evaluation example excretion experimental exposure assessment extrapolation factors Figure function gene genetic glucuronidation glutathione glutathione S-transferases groups Health hormesis human increased induced ingestion inhalation intake interactions kinetics levels linear liver lung measured mechanism medicine metabolism metabolites methods mutagenic occur omeprazole oral organ oxidation parameters pathways PBPK model Pharmaceuticals pharmacokinetic physiological plasma poisons population potential predict protein rats reactions receptor regulatory relationship response risk assessment rodent safety sample significant skin soil specific statistical substrate threshold tion tissue toxicity toxicokinetic Toxicol Appl Pharmacol toxicology tumor uptake variables vitro vivo xenobiotic zidovudine