Breast Cancer: A Lobar Disease

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Tibor Tot
Springer Science & Business Media, Nov 26, 2010 - Medical - 216 pages
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The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts in their respective areas, gather evidence from the perspectives of epidemiology, genetics, radiology, anatomy, developmental biology, morphology, endoscopy, ultrasound and therapeutics to give the reader a full picture of recent developments regarding the sick lobe hypothesis. Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.
 

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Contents

The Theory of the Sick Lobe
1
Lobar Anatomy of Human Breast and Its Importance for Breast Cancer
18
Breast Cancer May Originate In Utero The Importance of the Intrauterine Environment for Breast Cancer Development
39
Genetic Alterations in Normal and Malignant Breast Tissue
53
The Role of Ductal Lavage A Cautionary Tale
67
The Distribution of the Earliest Forms of Breast Carcinoma
78
The Implications of the Imaging Manifestations of Multifocal and Diffuse Breast Cancers
87
Lobar Ultrasound of the Breast
153
The Lobar Distribution of the Lesions in Breast Carcinoma Ductoscopy and Surgery
163
Stop Breast Cancer Now Imagining Imaging Pathways Toward Search Destroy Cure and Watchful Waiting of Premetastasis
167
Epilogue The Diseased Breast Lobe in the Context of XChromosome Inactivation and Differentiation Waves
204
Index
211
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About the author (2010)

Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

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