Laser-Driven Particle Acceleration Towards Radiobiology and Medicine

Front Cover
Antonio Giulietti
Springer, May 4, 2016 - Science - 320 pages
This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.
 

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Contents

1 Lasers Offer New Tools to Radiobiology and Radiotherapy
1
Part I Updating Radiobiology Radiotherapy andRadiation Safety
16
2 LaserPlasma Accelerators Based Ultrafast Radiation Biophysics
19
3 Cyberknife Dose Fractioning for Clinical Protocols
51
An OMICS Approach in Radiobiology
67
5 Radiological Safety in Laser Facilities
99
Part II Updating Laserdriven ElectronAcceleration and Dosimetry
133
6 Generation of MultiGeV Electron Beams and Biomedical Applications
135
8 AllOptical XRay and γRay Sources from Ultraintense LaserMatter Interactions
183
9 Dosimetry of LaserDriven Electron Beams for Radiobiology and Medicine
203
Part III Updating Laserdriven Ion Accelerationfor Biomedical Applications
220
State of the Art and Applications
221
11 Biological Responses Triggered by LaserDriven Ion Beams
249
12 High Resolution Ion and Electron Beam Radiography with LaserDriven Clustered Sources
271
13 Recent Progress in Laser Ion Acceleration
295
Index
315

7 Ionization Induced Electron Injection in Laser Wakefield Acceleration
163

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About the author (2016)

Antonio Giulietti is a physicist operating at INO (National Institute of Optics, Italy). He has been CNR Research Director and Head of the Unit "Adriano Gozzini" of INO. He founded ILIL (Intense Laser Irradiation Laboratory) in the CNR Campus of Pisa which has been operating for more than 20 years with scientific output and international collaboration making ILIL a primary reference in the domain of laser-plasmas. AG is author of more than 200 papers published on international refereed journals, mainly in the field of laser and plasma physics, plasma instabilities relevant to Inertial Fusion, radiation from plasmas, laser-driven particle acceleration and their biomedical potential. AG has organized and chaired a large number of international conferences on these topics. He is member of the International Advisory Board of the International Conference on High Energy Density Science, annually held in Yokohama. His research group has been supported by CNR, Italian Ministry of Education, Italian Ministry of Health, European Union, Extreme light Infrastructure (ELI), CEA (France), JSPS (Japan). AG has been very active in teaching and tutoring students and young scientists. Young scientists trained in the AG' lab are today Professors or Researchers in prestigious Universities or Research Institutions, including Universities of Pisa, Siena, Milano, Bordeaux, Oxford, Belfast, Ecole Polytechnique in Palaiseau, CEA-Saclay, BMI-Berlin, Rutherford Appleton Laboratory. In the last ten years 2006-2015 AG devoted most of his work at studying possible medical uses of laser-driven particle accelerators. Experiments performed in Pisa and at CEA-Saclay led to the discovery of a high efficiency acceleration regime allowing the production of electron bunches whose charge and kinetic energy are suitable for radiotherapy. Those electrons were also used to drive a gamma sources and produce photo-activation, so opening a perspective of interest for nuclear medicine. In the meantime AG promoted R&D studies to achieve a practical usability of laser-driven accelerators in radiobiology and clinics, also in collaboration with CEA-Saclay and University of Osaka. In this framework he recently published (2015) a review paper on “Laser-Plasma Particle Sources for Biology and Medicine”.