Nanoscale Insights into Ion-Beam Cancer Therapy

Front Cover
Andrey V. Solov’yov
Springer, Dec 7, 2016 - Science - 498 pages

This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

 

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Contents

Multiscale Physics of IonBeam Cancer Therapy
1
Propagation of Swift Protons in Liquid Water and Generation of Secondary Electrons in Biomaterials
61
Monte CarloBased Modeling of Secondary Particle Tracks Generated by Intermediate and LowEnergy Protons in Water
99
Ion Collisions with Biomolecules and Biomolecular Clusters
121
Dissociative Electron Attachment to Biomolecules
159
Photoprocesses with Biomolecules in the Gas Phase
209
IrradiationInduced Processes with Atomic Clusters and Nanoparticles
237
On the Quantum Description of Irradiation Dynamics in Systems of Biological Relevance
277
ThermoMechanical Damage of Biomolecules Under IonBeam Radiation
339
Predictive Assessment of Biological Damage Due to Ion Beams
359
The ARGENT Project
379
Biophysics Modeling to Optimize Ion Beam Cancer Therapy
435
Treatment Planning Systems and Hadron Therapy Practice in France
467
Author Index
495
Subject Index
497
Copyright

Multiscale Modelling of Molecular Processes for Biomedical and Nanotechnology Applications with MBN Explorer
311

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About the author (2016)

Professor Andrey Solov'yov is Editor-in-Chief of EPJD Atomic, Molecular, Optical and Plasma Physics from January 2015. He is Scientific and Executive Director of the MBN Research Center, Frankfurt am Main, Professor at the Peter the Great Saint-Petersburg Polytechnic University and the Leading Research Fellow at the A.F. Ioffe Physical-Technical Institute, Russian Academy of Sciences, Correspondent Member of European Academy of Sciences, Arts and Literature, Coordinator of several large European Projects in the interdisciplinary fields of Physics, Chemistry, Biology and Material Science, author / co-author of large number of research articles in high impact journals and books.

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