Environmental Radiation Effects on Mammals: A Dynamical Modeling Approach

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Springer, Oct 14, 2016 - Science - 359 pages

Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use.

 

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Contents

1 Effects of Acute and Chronic Irradiationon the BloodForming System
1
2 Effects of Nonuniform Acute Irradiationon the BloodForming System
66
3 The Small Intestine as a Target for Radiation
91
4 Radiation and Humoral Immunity
111
5 Modeling of Autoimmune Processes
141
6 IndividualBased Approach to Radiation Risk Assessment
160
7 Effects of Acute and Chronic Irradiation on Human Hematopoiesis
201
8 Radiogenic Leukemia Risk Assessment
269
9 Radiation and Skin
297
Conclusions
353
Index
356
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About the author (2016)

Dr. Olga A. Smirnova is a physicist and researcher at the Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, Moscow, Russia. She uses the framework of developed deterministic mathematical models to investigate the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems, including hematopoiesis, small intestine and humoral immunity, as well as on the development of autoimmune diseases. Dr. Smirnova's fields of study and expertise include modeling the dynamics of various biological systems in mammals exposed to acute/chronic radiation.

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