Capillary Electrophoresis - Mass Spectrometry (CE-MS): Principles and Applications

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John Wiley & Sons, Sep 13, 2016 - Science - 368 pages
This monograph offers the reader a complete overview on both principles and applications of CE-MS. Starting with an introductory chapter on detection in CE, also related and more specialized techniques such as electrophoretic and chromatographic preconcentration are discussed. A special emphasis is put on CE-MS interfaces, which are described in detail. In a separate chapter, attention is paid to sheath-liquid interfacing. The developments and possibilities of microchip CE-MS are also described. Applications to all relevant areas are discussed in distinct chapters, each written by experts in the respective fields.
Besides applications in pharmaceutical analysis and bioanalysis, recent implementations in food science, forensic analysis, analysis of intact proteins, metabolomics and proteomics are highlighted. MS is a perfectly appropriate detection system for CE, as efficient separation is coupled to sensitive and selection detection. Moreover, MS can provide structure information on the separated compounds. CE-MS has now been developed into a strong hyphenated system complementary to LC-MS. This monograph is an unique source of knowledge for everyone dealing with and interested in CE-MS.
 

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Contents

Electrospray Ionization Interface Development for Capillary
7
Role Parameters and Optimization
41
Recent Developments of Microchip Capillary Electrophoresis Coupled
67
OnLine Electrophoretic Electrochromatographic
103
CEMS in Drug Analysis and Bioanalysis
129
CEMS for the analysis of intact proteins
159
CEMS in Food Analysis and Foodomics
193
CEMS in Forensic Sciences with Focus on Forensic Toxicology
217
CEMS in Metabolomics
293
Strategies
315
Abbreviations
339
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About the author (2016)

Gerhardus (Ad) de Jong studied chemistry in Utrecht, the Netherlands, and received his Ph.D. at the Free University of Amsterdam. He worked for Duphar, a pharmaceutical company in Weesp, the Netherlands, in the department Analytical Research. Subsequently, he returned to the Free University as associate professor in the Department of Analytical Chemistry. In 1990, he again moved to the pharmaceutical industry and was appointed to section head Chromatography of Solvay Duphar. In 1995, he was appointed professor in Analytical Chemistry and Pharmaceutical Analysis at the University Centre for Pharmacy, Groningen, the Netherlands, and since 2001, he is professor in Pharmaceutical Analysis at the Department of Pharmaceutical Sciences, Utrecht University.
Prof. de Jong is (co-)author of more than 300 papers in various scientific journals and some book chapters. He is co-author of a book on chromatography and was editor of the Journal of Chromatography B from 1998 to 2003. His research interests encompass separation techniques and their applications in pharmaceutical analysis, bioanalysis and analysis of biomacromolecules.

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