Natural Products Targeting Clinically Relevant Enzymes
Paula B. Andrade, Patrícia Valentão, David M. Pereira
John Wiley & Sons, Dec 4, 2017 - Medical - 352 pages
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more.
By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
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acetogenins ACGs AChE agents alkaloids analogues angiotensin anthocyanins anti‐cancer anti‐inflammatory antifungal antihypertensive antimalarial antioxidant apoptosis BACE1 inhibitory activity Bee venom berberine bioactive bioavailability Biochem Biol biological cancer cells Chem chemical Chen clinical co‐workers compounds curcumin cyanobacterium cyclooxygenase cytotoxic derivatives diabetes disease dolastatin drug discovery eicosanoids enzyme enzyme inhibitors exhibited extract Figure flavonoids Food Chem Guggulsterone HIV‐1 reverse transcriptase Human synovial IC50 values ICso induces apoptosis inflammation inflammatory inhibitory effects integrase isolated kinase largazole Lett Luesch marine mechanism mediated metabolites metformin mice mitochondrial molecular molecules natural products novel OCH3 OH O OH OH OH pancreatic pathways peptides Pharm Pharmacol phenolic phospholipase A2 PLA2 plants potent Prod protease protein quercetin rats reported resveratrol reverse transcriptase Silibinin sPLA2 sponge structure studies suppressing synthesis synthetic target therapeutic trabectedin treatment Triptolide triterpene tumour ursolic acid vitro vivo Wang Zhang µg/ml