Natural Products Targeting Clinically Relevant Enzymes

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Paula B. Andrade, Patrícia Valentão, David M. Pereira
John Wiley & Sons, Dec 4, 2017 - Medical - 352 pages
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The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more.
By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
 

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Contents

Molecular Targets of Clinically Relevant Natural Products
19
Natural Angiotensin Converting Enzyme ACE Inhibitors
45
Phospholipase A2 Inhibitors of Marine Origin
69
βSecretase BACE1 Inhibitors from Natural Products
93
Hypoglycaemic Effects of Plants Food Constituents via Inhibition
135
Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid
163
AntiHIV Natural Products
209
Therapeutic
225
Targeting Enzymatic Pathways with MarineDerived
255
New Enzyme Inhibitors
277
Relevance
297
Index
319
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About the author (2017)

PAULA B. ANDRADE is Associate Professor at the Faculty of Pharmacy of the University of Porto. As head of the Pharmacognosy lab, she also coordinates the natural products group of the REQUIMTE/LAQV, an institute active in Green Chemistry, and evaluates research projects for various international entities. Her research on bioactive substances originating from matrices of marine and terrestrial origin was published in more than 30 book chapters and more than 300 articles in international journals.

PATRICIA VALENTÃO obtained her PhD in Pharmaceutical Sciences at the University of Porto for work on pharmacognosy. She was appointed Assistant Professor at the Faculty of Pharmacy, University of Porto in 2007. Her research focuses on qualitative and quantitative metabolite profiling of terrestrial and marine natural matrices with the goal to reveal composition/activity relationships of these compounds in various clinically-relevant areas. Patricia Valentão is member of the REQUIMTE/LAQV Institute of Green Chemistry and editorial board member of the "EJournal of Chemistry". She (co)authored more than 30 book chapters and more than 250 articles in international journals.

DAVID M. PEREIRA obtained his PhD in Pharmaceutical Sciences at the University of Porto for work on phytochemistry and pharmacognosy. In 2014 he was appointed Assistant Professor at the Faculty of Pharmacy of the same university. David Pereira edited one book, contributed more than 20 book chapters and over 60 papers covering research areas of natural products, inflammation, drug discovery and analytical techniques. He also serves in the Editorial Board of several journals related to natural products and analytical techniques. He is appointed expert in the "Global Burden of Disease" program of the University of Washington, and reviewer/consultant in Biomedical Sciences for several European institutions.

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