Nitroalkanes: Synthesis, Reactivity, and Applications

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John Wiley & Sons, Feb 23, 2021 - Science - 320 pages

Discover a comprehensive exploration of recent progress in the preparation of nitroalkanes from two leading voices in the field

Nitroalkanes: Synthesis, Reactivity, and Applications delivers a thorough summary of the importance of nitroalkanes in organic synthesis. The book covers their preparation, transformation into other functional groups, like carbonyls and amines, and their use in the formation of single carbon-carbon or double carbon-carbon bonds. The distinguished authors have included chapters on acyclic and cyclic alpha-nitro ketones as well as the synthesis of cyclopropanes and spiro ketals.

The book provides treatments of the application of nitroalkanes for the synthesis of important heterocycles, poly-functionalized structures, natural products, and compounds of biological and pharmaceutical interest. A one-stop resource in a topic that hasn???t been fully addressed by any other book in decades, this book covers the most important synthetic routes toward nitroalkanes.

Readers will also benefit from the inclusion of:

  • A thorough introduction to the synthesis of nitroalkanes, as well as the transformation of the nitro group into other functionalities
  • An exploration of the formation of C-C single bonds, C=C double bonds, and the breaking of C3C bonds from cyclic alpha-nitro ketones
  • Discussions of acyclic alpha-nitro ketones, nitroalkanes as precursors of cyclopropanes, and the synthesis of spiro ketals
  • An examination of the preparation and synthetic applications of 1,3-Dinitroalkanes
  • Perfect for organic chemists, natural products chemists, and catalytic chemists, Nitroalkanes: Synthesis, Reactivity, and Applications will also earn a place in the libraries of medicinal chemists seeking a one-stop resource for the most recent developments in the preparation of nitroalkanes, their functionalization, and their applications.


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    Reduction of the Nitro Group into Amines
    Nitro Group to Carbonyl Nef Reaction
    Conjugate Addition of Nitroalkanes to ElectronPoor Alkenes
    Formation of CC Bond by Coupling Nitroalkanes with
    Synthesis and Reactivity of 13Dinitroalkanes
    Formation of CarbonCarbon Double Bonds via Nitrous Acid
    𝛂Nitrocycloalkanones Synthesis and Reactivity
    Synthesis and Reactivity
    Nitroalkanes as Source of Spiroketals

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    About the author (2021)

    Roberto Ballini is Professor of Organic Chemistry at the University of Camerino in Italy. His research focus is on organic synthesis, with a particular emphasis on aliphatic nitro compounds. He has published over 250 scientific articles and edited two books.

    Alessandro Palmieri is Associate Professor at the University of Camerino in Italy. His research focus is on eco-friendly processes for the formation of C-C and C-X bonds and flow chemical protocols for the synthesis of fine chemicals. He has published over 100 scientific articles.

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