3D Analysis of the Myocardial Microstructure: Determination of Fiber and Sheet OrientationsThe master thesis of Johanna Maria Ticar reveals high-resolution insights into the myocardial microstructure and illustrates that cardiac muscle fibers are straight, running in parallel with one preferred fiber direction, however, deposits such as fat seem to compromise the regular and compact structure. Second harmonic generation imaging combined with optical tissue clearing is an accurate method for determining the three-dimensional muscle fiber and sheet orientations and hence, allows the calculation of fiber rotation throughout the ventricle wall. |
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3D Analysis of the Myocardial Microstructure: Determination of Fiber and ... Johanna Maria Ticar No preview available - 2015 |
Common terms and phrases
3Dslicer 9 LV angles displayed anisotropic areas display orientations available to download biaxial BioImageSuite blue areas display cardiac muscle fibers clearing agent coefficient of determination colour freely available colours ranging Cox & Kable dark blue dark red 100 dehydration density of fibers Depiction determination R2 diffusion tensor imaging diffusion-weighted image dispersion parameter ejection fraction endocardial endocardium epicardial epicardium fiber rotation fibers run figure in colour heart muscle fibers heart samples Holzapfel & Ogden human heart image stack in-plane intensity plot laser left ventricle left ventricle wall location parameter low fiber density multi-photon microscopy Myocardial Microstructure myocardium myocytes optical clearing Original figure perimysium porcine heart preferred fiber orientations ranging from dark Red areas show relative amplitudes respective depth right ventricle Rohmer sample VIII sample XXI Schriefl second harmonic sheets SHG imaging specimen visualization Volume rendering volume-rendered wall thickness website www.springer.com x-axis z-stack