Towards Offline PET Monitoring at a Cyclotron-Based Proton Therapy Facility: Experiments and Monte Carlo Simulations

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Springer, May 30, 2016 - Science - 86 pages

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

 

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Contents

1 Introduction
1
2 Theoretical background of protontherapy and PET imaging
5
3 Monte Carlo modeling of theclinical proton beam
17
4 PET activation studies
38
5 Conclusion and Outlook
77
Bibliography
80
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About the author (2016)

Matthias Würl wrote his Master’s Thesis at the chair of Medical Physics at the Ludwig-Maximilians University Munich. He is now a PhD student at the same department, working on transmission imaging with laser-accelerated ions.

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