Epigenetic Epidemiology

Front Cover
Karin B. Michels
Springer Science & Business Media, Jan 3, 2012 - Medical - 448 pages

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis.

With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

 

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Contents

Chapter 4 Laboratory Methods in Epigenetic Epidemiology
36
Chapter 5 Biostatistical Methods in Epigenetic Epidemiology
57
Chapter 6 Epigenome Changes During Development
77
Chapter 7 The Role of Epigenetics in the Developmental Origins of Health and Disease
105
Chapter 8 Epigenetics and Assisted Reproductive Technology
117
Chapter 9 Imprinting Disorders of Early Childhood
137
Chapter 10 The Utility of Twins for Epigenetic Analysis
161
Chapter 11 AgeRelated Variation in DNA Methylation
185
Chapter 14 Epigenetic Epidemiology of Infectious Diseases
269
Chapter 15 Epigenetic Epidemiology of Inflammation and Rheumatoid Arthritis
289
Chapter 16 Asthma Epigenetics Emergence of a New Paradigm?
307
Chapter 17 Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders
321
Chapter 18 Epigenetic Epidemiology of Psychiatric Disorders
343
Chapter 19 Epigenetic Epidemiology of Type 1 Diabetes
377
Chapter 20 Epigenetic Epidemiology of Obesity Type 2 Diabetes and Metabolic Disorders
401
Chapter 21 Epigenetic Epidemiology of Atherosclerosis
422

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