Karin B. Michels
Springer Science & Business Media, Jan 3, 2012 - Medical - 448 pages
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis.
With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
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Chapter 4 Laboratory Methods in Epigenetic Epidemiology
Chapter 5 Biostatistical Methods in Epigenetic Epidemiology
Chapter 6 Epigenome Changes During Development
Chapter 7 The Role of Epigenetics in the Developmental Origins of Health and Disease
Chapter 8 Epigenetics and Assisted Reproductive Technology
Chapter 9 Imprinting Disorders of Early Childhood
Chapter 10 The Utility of Twins for Epigenetic Analysis
Chapter 11 AgeRelated Variation in DNA Methylation
Chapter 14 Epigenetic Epidemiology of Infectious Diseases
Chapter 15 Epigenetic Epidemiology of Inflammation and Rheumatoid Arthritis
Chapter 16 Asthma Epigenetics Emergence of a New Paradigm?
Chapter 17 Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders
Chapter 18 Epigenetic Epidemiology of Psychiatric Disorders
Chapter 19 Epigenetic Epidemiology of Type 1 Diabetes
Chapter 20 Epigenetic Epidemiology of Obesity Type 2 Diabetes and Metabolic Disorders