The Physical Basis of Biochemistry : the Foundations of Molecular Biophysics
The objective of this book is to provide a unifying approach to the study of biophysical chemistry for the advanced undergraduate who has had a year of physics, organic chem istry, calculus, and biology. This book began as a revised edition of Biophysical Chemistry: Molecules to Membranes, which Elizabeth Simons and I coauthored. That short volume was written in an attempt to provide a concise text for a one-semester course in biophysical chemistry at the graduate level. The experience of teaching biophysical chemistry to bi ologically oriented students over the last decade has made it clear that the subject requires a more fundamental text that unifies the many threads of modem science: physics, chem istry, biology, mathematics, and statistics. This book represents that effort. This volume is not a treatment of modem biophysical chemistry with its rich history and many contro versies, although a book on that topic is also needed. The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. I have three primary objectives in this volume: one, to provide a unifying picture of the interdisciplinary threads from which the tapestry of biophysical studies is woven; two, to provide an insight into the power of the modeling approach to scientific investigation; and three, to communicate a sense of excitement for the activity and wholesome argument that characterize this field of study
1 online resource (xxii, 567 pages)
9781475729634, 1475729634
851803427
Print version:
1 Introduction to the Principles and Practice of Biophysical Chemistry
2 Physical Thoughts, Biological Systems: The Application of Modeling Principles to Understanding Biological Systems
3 Probability and Statistics
4 Physical Principles: Energy
The Prime Observable
5 Physical Principles: Mechanics and Motion
6 Physical Principles: Waves
7 Physical Principles: Electrostatics
8 Physical Principles: Electromagnetics
9 Physical Principles: Quantum Mechanics
10 Chemical Principles
11 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics
12 The Whole Is Greater than the Sum of Its Parts: Entropy and the Second Law
13 Which Way Is That System Going? The Gibbs Free Energy
14 Friends and Neighbors
Interactions in a System: Phase Equilibria
15 Spectroscopy: Analysis of Structure
16 Analysis of Structure: Microscopy
17 Scenic Overlook Backward and Forward
18 Water: A Unique Structure, a Unique Solvent
19 Ion-Solvent Interactions
20 Ion-Ion Interactions
21 Lipids in Aqueous Solution: The Formation of the Cell Membrane
22 Constructing a Biological State Space
23 Macromolecules in Solution
24 Molecular Modeling: Mapping Biochemical State Space
25 The Electrified Interface
26 Forces Across Membranes
27 Transport: A Nonequilibrium Process
28 Flow in a Chemical Potential Field: Diffusion
29 Flow in an Electrical Field: Conduction
30 Electrokinetic Phenomena
31 Kinetics: Chemical Kinetics
32 Kinetics: Enzymes and Electrons
Epilogue
Appendixes
Appendix A Mathematical Methods
A.1 Units and Measurement
A.2 Trigonometric Functions
A.3 Expansion Series
A.4 Differential and Integral Calculus
A.4.1 Partial Differentiation
A.5 Vectors
A.5.1 Addition and Subtraction
A.5.2 Magnitude of a Vector
A.5.3 Multiplication
Appendix B Fictitious and Pseudoforces: The Centrifugal Force
Appendix C The Determination of the Field from the Potential in Cartesian Coordinates
Appendix D Hamilton's Principle of Least Action/Fermat's Principle of Least Time
Appendix E Geometrical Optics
E.1 Reflection and Refraction of Light
E.2 Mirrors
E.2.1 The Plane Mirror
E.2.2 The Concave Mirror
E.3 Image Formation by Refraction
E.4 Prisms and Total Internal Reflection
Appendix F Derivation of the Energy of Interaction Between Two Ions
Appendix H Derivation of the Clausius-Clapeyron Equation
Appendix I Derivation of the van't Hoff Equation for Osmotic Pressure
Appendix J Derivation of the Work to Charge and Discharge a Rigid Sphere
Appendix K Quantum Electrodynamics
Appendix L Adiabatic and Nonadiabatic Transitions
Appendix M Fermi's Golden Rule
Physical Constants
Answers to Selected Problems
English
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